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mTOR kinase is really a critical molecule while in the induction of autophagy. The Akt signaling pathway can activate mTOR to inhibit autophagy. Cepharanthine can induce autophagy and apoptosis in most cancers cells by regulating the Akt/mTOR or AMPK/mTOR signaling pathways [forty two]. mTOR kinase can inhibit autophagy and apoptosis, and AKT can i

g. IPF and scleroderma), nevertheless the pathophysiology of those designs, relying on direct administration of drug to tissue, differs enormously from scientific bleomycin?induced lung fibrosis. Alternatively, systemic administration of a pro?fibrotic drug like bleomycin should more closely mimic the inflammatory and fibrotic processes witnessed i